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Dolomite Bio introduces new single nucleus RNA-Seq chip for DroNc-Seq

PressReleasePing - September 01, 2017 -Dolomite Bio is pleased to announce the launch of a new chip for DroNc-Seq1, enabling high throughput single nucleus RNA-Seq using droplet microfluidics. The single nucleus RNA-Seq chip – based on the company’s established scRNA-Seq chip – is designed to produce smaller droplets, allowing straightforward, low cost profiling of thousands of nuclei. DroNc-Seq is a novel single cell RNA-Seq methodology which uses isolated nuclei instead of whole cells. Nuclei can be quickly and easily isolated from frozen or lightly fixed tissues – including tissues which are difficult to isolate individual cells from. This avoids lengthy and stressful manipulation of live cells, which could perturb expression profiles. Remarkably, the transcriptomes acquired are very similar to those from whole cells, albeit with a lower total transcript capture rate and greater representation of nuclear RNA and pre-mRNA. The single nucleus RNA-Seq chip – compatible with Dolomite Bio’s Single Cell RNA-Seq System – is ideal for nuclei encapsulation, and has been optimized for the generation of smaller diameter droplets than those used in standard scRNA-Seq protocols. The single nucleus RNA-Seq chip for DroNc-Seq is available now. For more information or to order, visit 1 Habib, N et al. (2017) DroNc-Seq: Deciphering cell types in human archived brain tissues by massively-parallel single nucleus RNA-seq. bioRxiv, 115196. Dolomite Bio Dolomite Bio creates innovative products for high throughput single cell research. By encapsulating single cells in microfluidic droplets, our products enable rapid analysis of thousands or millions of individual cells and their biological products. Dolomite Bio is a brand of Blacktrace Holdings Ltd (, a world leader in Productizing Science®. Our Head Office is based in Royston (near Cambridge), UK and we have regional offices in the USA, Japan, India and Brazil. Dolomite Bio’s products include μEncapsulator System and RNA Seq system, suitable for use in many applications such as isolating antibody coding sequencing, profiling T cell receptors, droplets for FACS-sorting libraries and encapsulating cells in gel microbeads. To find out more about Dolomite Bio, please visit

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